Special precautions for use
Special precautions for safe use in the target species:
This veterinary medical product should only be used in dogs with cardiac insufficiency. Do not exceed the recommended dose.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Adverse events
Dog:
Rare (1 to 10 animals / 10,000 animals treated): | A moderate positive chronotropic effect and vomiting.1 Transient diarrhoea, anorexia or lethargy |
1 These effects are dose-dependent and can be avoided by reducing the dose in these cases.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy, lactation or lay
In studies with rats and rabbits pimobendane had no effect on fertility and embryotoxic effects only occurred at maternotoxic doses. In experiments with rats it has been shown that pimobendan is excreted into milk.
No information is available on the safety of this veterinary medical product in pregnant and lactating bitches. Therefore, this veterinary medical product should only be administered to pregnant and lactating bitches if the expected therapeutic benefits outweigh the potential risk.
Interaction with other medicinal products and other forms of interaction
The pimobendan-induced increase in contractility of the heart is attenuated in the presence of the calcium antagonist verapamil and the β-antagonist propranolol.
In pharmacological studies no interaction between the cardiac glycoside ouabain and pimobendan was detected.
Symptoms of overdose (and where applicable, emergency procedures and antidotes)
In case of overdose symptomatic treatment should be initiated.
Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance
Not applicable.
Withdrawal periods
Not applicable.