Target species
Horses.
Indications for use for each target species
For infiltration, nerve block, intraarticular and epidural anaesthesia in horses.
Contraindications
None.
Special warnings
None.
Special precautions for use
Special precautions for safe use in the target species:
Care should be taken to avoid intra-vascular injection by aspiration prior to and during administration.
The analgesic effect of mepivacaine, when used as part of a lameness investigation, begins to subside after 45-60 minutes. However, sufficient analgesia may persist to affect gait beyond two hours.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Care should be taken to avoid accidental self-injection or skin contact.
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
Wash splashes from skin or eyes immediately.
Special precautions for the protection of the environment:
Not applicable.
Adverse reactions
Horses:
Very rare (<1 animal / 10 000 animals treated, including isolated reports): | Injection site swellinga; Central nervous system disorderb, convulsionc; Cardiac depressionc; Respiratory depressionc. |
a Transient.
b Local anaesthetics used in excess can cause systemic toxicity characterised by CNS effects.
c If systemic toxicity occurs as a result of inadvertent intra-vascular injection, the administration of oxygen to treat cardio-respiratory depression and diazepam to control convulsions should be considered.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy, lactation and lay
Pregnancy and lactation:
Can be used during pregnancy and lactation.
Interaction with other medicinal products and other forms of interaction
None known
Administration routes and dosage
Infiltration, perineural use, epidural use and intraarticular use.
Full aseptic precautions should be observed when injecting the veterinary medicinal product.
For infiltration: As required but as a guide 2-5 ml.
For nerve block: 2-10 ml depending on location.
For intraarticular anaesthesia: 5 ml.
For epidural anaesthesia: 4-10 ml depending on the depth and extent of anaesthesia required.
In all instances the dosage should be kept to the minimum required to produce the desired effect. The depth and extent of anaesthesia should be determined by pressure with a blunt point, such as the tip of a ball point pen, before commencing manipulations. The duration of action is about 1 hour. It is recommended that the skin should be shaved and thoroughly disinfected prior to the intraarticular or epidural administration.
Symptoms of overdose (and where applicable, emergency procedures and antidotes)
Local anaesthetics used in excess can cause systemic toxicity characterised by CNS effects.
If systemic toxicity occurs as a result of inadvertent intravascular injection, the administration of oxygen to treat cardio-respiratory depression and diazepam to control convulsions should be considered.
Withdrawal periods
Not authorised for use in horses intended for human consumption.