ATCvet code: QP53AX15
Pharmacodynamics
Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of insects and acarids. Fipronil kills fleas within 24 hours, ticks (Dermacentor spp., Rhipicephalus spp., Ixodes spp.) and lice within 48 hours post-exposure.